Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain†
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株式会社王子化学研究所
【第3類医薬品】 滋養強壮薬α 160錠
Figure US06949530-20050927-C00008
Current strategy to generate an amidine group on my functionalized indole boronic acid. My next step involves a Suzuki coupling between the boronic acid and my an aryl-halide fragment. Will the boronic acid be affected by the aluminum reagent since Al may chelate to boron? What are your thoughts?
The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells