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Alleged image fraud at MD Anderson Cancer Center (Bharat Aggarwal lab)Guggulsterone inhibits osteoclastogenesis induced by receptoractivator of nuclear factor-kappaB ligand and by tumor cells bysuppressing nuclear factor-kappaB activation.Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumolleads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis inleukemia cells.Zerumbone abolishes RANKL-induced NF-kappaB activation,inhibits osteoclastogenesis, and suppresses human breastcancer-induced bone loss in athymic nude mice.Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibitenhanced anti-proliferative, anti-inflammatory, andchemosensitization potential.Gossypol induces death receptor-5 through activation of theROS-ERK-CHOP pathway and sensitizes colon cancer cells toTRAIL.
