PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis Arginase 1 is a key driver of immune suppression in pancreatic cancer The CD73 immune checkpoint promotes tumor cell metabolic fitness
Western blot - Anti-Cleaved PARP1 antibody (ab4830)
Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy
PARP in DNA damage response
The Critical Role of PARPs in Regulating Innate Immune Responses
Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy
DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases?
Regulation of chromatin structure by poly(ADP-ribosyl)ation