Sampling the conformational space of the catalytic subunit of human γ-secretase A mechanism of uncompetitive inhibition of the serotonin transporter Mechanism of Ca2+ transport by ferroportin Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Chemical Structure - γ–Secretase Inhibitor I (ab145891)
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase Amyloid-beta Peptides: How γ-secretase hits a moving target Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase Mitochondrial protein import clogging as a mechanism of disease
生化学 SEIKAGAKUJournal of Japanese Biochemical Society
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Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans Differential modification of the C-terminal tails of different α-tubulins and their importance for microtubule function in vivo Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset
New Drug Approvals Tag Archives: γ-secretase inhibitorDETAILS WILL BE UPDATED SOON………….George V. De LuccaPatrice GillPICTURES WILL BE UPDATED………….Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid TumorsDiscovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors
CryoEM γ-Secretase Structures Nail APP, Notch Binding CommentsReferencesFurther Reading
γ-Secretase — Regulated Signaling and Alzheimer's Disease
Protein pigeon homolog
