通常/修飾心筋型トロポニンIのセット
Cardiac Troponin I Diversity Kit
A. Left, schematic representation of F-actin disassembly by Coronin 1B, Cofilin 1, and AIP1. Right, snapshot of preassembled actin filaments (in cyan) being disassembled by Coronin 1B, Cofilin 1 (in yellow), and AIP1. B. Same as A but with TMP added to the reaction mixture. C. Treadmilling reconstitution assay in which filaments are actively being assembled at one end by mDia1 (formin) while simultaneously being disassembled by Coronin 1B, Cofilin 1 (in yellow), and AIP1 at the other end. Decoration with different TPM isoforms results in filaments displaying different turnover behavior.TropomyosinOverview of the biologically most relevant TPM isoforms indicated by both the old (in parentheses) and new nomenclature. Left, overview of alternative splicing and exon composition of the different TPM isoforms. Right, cryo-EM structure of F-actin and skeletal muscle TPM with color-coded exons (adapted from von der Ecken et al., 2013), and potential labeling sites represented as stick-and-balls.
Development of anti-tropomyosin drugs, anti-cancer drugs