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trends timeline for %E3%82%A8%E3%83%83%E3%82%B7%E3%82%A7%E3%83%B3%E3%83%A2%E3%83%BC%E3%82%B6%E3%83%BC%E3%83%BB%E3%82%BF%E3%83%8A%E3%83%99%E9%96%8B%E8%A3%82%20-%20Eschenmoser%20fragmentation