Similar to Wine

Enlightened Sound Daemon

Erlang (programming language)

ERP5

Etherpad

Exa (command-line utility)

Exaile

Expr

EZ Publish

F-Spot

Falkon

Far Manager

Fetchmail

Fastest Fourier Transform in the West

FindBugs

Firebird (database server)

Firestarter (firewall)

Firewalld

Flask (web framework)

Flutter (software)

FMSX

Foliate (software)

FOLIO (library services platform)

Foresight Linux